Spontaneous Brain and Spinal Cord/Nerve Neoplasms in Aged Sprague-Dawley Rats
نویسندگان
چکیده
منابع مشابه
Spontaneous neoplastic lesions in aged Sprague-Dawley rats.
Neoplastic lesions were observed in untreated aged Sprague Dawley (SD) rats throughout their lifespan starting at 5 weeks. Their mean survival times were 89 to 105 weeks of age. The total tumor incidences were 70 to 76.7% and 87 to 95.8% in males and females, respectively. The common neoplasmas were pituitary adenoma and adrenal pheochromocytoma in both sexes, testicular Leydig cell tumor in ma...
متن کاملSpontaneous tumors in Sprague-Dawley rats and Swiss mice.
A spontaneous tumor incidence of 45% was noted in 360 Sprague-Dawley rats (179 males and 181 females) and a 26% incidence was seen in 254 Swiss mice (101 males and 153 females) used as untreated control animals in an 18month series of carcinogenesis experiments. The percentage of female rats with tumors was almost double that of males, which difference was accounted for chiefly by the high inci...
متن کاملSpontaneous Tumors in Sprague-Dawley Rats and Swiss Mice1
A spontaneous tumor incidence of 45% was noted in 360 Sprague-Dawley rats (179 males and 181 females) and a 26% incidence was seen in 254 Swiss mice (101 males and 153 females) used as untreated control animals in an 18month series of carcinogenesis experiments. The percentage of female rats with tumors was almost double that of males, which difference was accounted for chiefly by the high inci...
متن کاملProtein expression is altered during spontaneous sleep in aged Sprague Dawley rats.
Age-related changes in brain function include those affecting learning, memory, and sleep-wakefulness. Sleep-wakefulness is an essential behavior that results from the interaction of multiple brain regions, peptides, and neurotransmitters. The biological function(s) of sleep, however, remains unknown due to a paucity of information available at the cellular level. Aged rats exhibit alterations ...
متن کاملUltrastructural studies of human adenovirus-produced retinoblastoma-like neoplasms in Sprague-Dawley rats.
Sixteen out of 85 Sprague-Dawley rats (18.8 per cent) developed solid medullary tumors in the left ocular cavity within 74 to 288 days after a single intravitreous inoculation of 0.015 to 0.03 ml. of fluid containing human adenovirus type 12, 10to 10 TCIDso HeLa cells per 0.1 ml. The left eye was inoculated within 24 hours after birth. Tumor-bearing rats were perfused with Karnovsky's fixative ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Toxicologic Pathology
سال: 1992
ISSN: 0192-6233,1533-1601
DOI: 10.1177/019262339202000404